AskDefine | Define toxoplasmosis

Dictionary Definition

toxoplasmosis n : infection caused by parasites transmitted to humans from infected cats; if contracted by a pregnant woman it can result in serious damage to the fetus

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parasitic disease

Extensive Definition

Toxoplasmosis is a parasitic disease caused by the protozoan Toxoplasma gondii. The parasite infects most warm-blooded animals, including humans, but the primary host is the felid (cat) family. Animals are infected by eating infected meat, by ingestion of faeces of a cat that has itself recently been infected, or by transmission from mother to fetus. Cats have been shown as a major reservoir of this infection.
Up to one third of the world's population is estimated to carry a Toxoplasma infection. The Centers for Disease Control and Prevention notes that overall seroprevalence in the United States as determined with specimens collected by the third National Health and Nutritional Assessment Survey (NHANES III) between 1988 and 1994 was found to be 22.5%, with seroprevalence among women of childbearing age (15 to 44 years) of 15%.
During the first few weeks, the infection typically causes a mild flu-like illness or no illness. After the first few weeks of infection have passed, the parasite rarely causes any symptoms in otherwise healthy adults. However, people with a weakened immune system, such as those infected with HIV, and fetuses, may become seriously ill, and it can occasionally be fatal. The parasite can cause encephalitis (inflammation of the brain) and neurologic diseases and can affect the heart, liver, and eyes (chorioretinitis).

History

The protozoan was first discovered by Nicolle & Manceaux, who in 1908 isolated it from the African rodent Ctenodactylus gundi, then in 1909 differentiated the disease from Leishmania and named it Toxoplasmosis gondii http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6W7G-4J55654-3-3&_cdi=6626&_user=427455&_orig=search&_coverDate=03%2F31%2F2006&_sk=999779996&view=c&wchp=dGLbVzb-zSkzS&md5=10087511e28d0e025255efed0d310bdf&ie=/sdarticle.pdf. The first recorded congenital case was not until 1923, and the first adult case not until 1940

Transmission

  • Ingestion of raw or partly cooked meat, especially pork, lamb, or venison containing Toxoplasma cysts. Infection prevalence in countries where undercooked meat is traditionally eaten, such as France, has been related to this transmission method. Oocysts may also be ingested during hand-to-mouth contact after handling undercooked meat, or from using knives, utensils, or cutting boards contaminated by raw meat.
  • Ingestion of contaminated cat faeces. This can occur through hand-to-mouth contact following gardening, cleaning a cat's litter box, contact with children's sandpits, or touching anything that has come into contact with cat faeces.
  • Drinking water contaminated with Toxoplasma.
  • Transplacental infection in utero.
  • Receiving an infected organ transplant or blood transfusion, although this is extremely rare.
Cats excrete the pathogen in their faeces for a number of weeks after contracting the disease, generally by eating an infected rodent. Even then, cat faeces are not generally contagious for the first day or two after excretion, after which the cyst 'ripens' and becomes potentially pathogenic. Studies have shown that only about 2% of cats are shedding oocysts at any one time, and that oocyst shedding does not recur even after repeated exposure to the parasite. Although the pathogen has been detected on the fur of cats, it has not been found in an infectious form, and direct infection from handling cats is generally believed to be very rare.

Pregnancy precautions

Congenital toxoplasmosis is a special form in which an unborn child is infected via the placenta. A positive antibody titer indicates previous exposure and immunity and largely ensures the unborn baby's safety. A simple blood draw at the first pre-natal doctor visit can determine whether or not the woman has had previous exposure and therefore whether or not she is at risk. If a woman receives her first exposure to toxoplasmosis while pregnant, the baby is at particular risk. A woman with no previous exposure should avoid handling raw meat, exposure to cat feces, and gardening (cat feces are common in garden soil). Most cats are not actively shedding oocysts and so are not a danger, but the risk may be reduced further by having the litterbox emptied daily (oocysts require longer than a single day to become infective), and by having someone else empty the litterbox. However, while risks can be minimized, they cannot be eliminated. For pregnant women with negative antibody titer, indicating no previous exposure to T. gondii, as frequent as monthly serology testing is advisable as treatment during pregnancy for those women exposed to T. gondii for the first time decreases dramatically the risk of passing the parasite to the fetus.
Despite these risks, pregnant women are not routinely screened for toxoplasmosis in most countries (France being the exceptions) for reasons of cost-effectiveness and the high number of false positives generated as the disease is so rare (an example of Bayesian statistics). As invasive prenatal testing incurs some risk to the fetus (18.5 pregnancy losses per toxoplasmosis case prevented
  • clindamycin — an antibiotic which, in combination with atovaquone, seemed to optimally kill cysts in mice.
However, in latent infections successful treatment is not guaranteed, and some subspecies exhibit resistance.

Biological modifications of the host

The parasite itself can cause various effects on the host body, some of which are not fully understood.

Reproductive changes

A recent study has indicated Toxoplasmosis correlates strongly with an increase in boy births in humans. According to the researchers, depending on the antibody concentration, the probability of the birth of a boy can increase up to a value of 0.72 ... which means that for every 260 boys born, 100 girls are born. The study also notes a mean rate of 0.60 to 0.65 (as opposed to the normal 0.51) for Toxoplasma positive mothers.

Behavioral changes

It has been found that the parasite has the ability to change the behavior of its host: infected rats and mice are less fearful of cats — in fact, some of the infected rats seek out cat-urine-marked areas. This effect is advantageous to the parasite, which will be able to sexually reproduce if its host is eaten by a cat. The mechanism for this change is not completely understood, but there is evidence that toxoplasmosis infection raises dopamine levels and concentrates in the amygdala in infected mice.
The findings of behavioral alteration in rats and mice have led some scientists to speculate that toxoplasma may have similar effects in humans, even in the latent phase that had previously been considered asymptomatic. Toxoplasma is one of a number of parasites that may alter their host's behaviour as a part of their life cycle. The behaviors observed, if caused by the parasite, are likely due to infection and low-grade encephalitis, which is marked by the presence of cysts in the brain, which may produce or induce production of a neurotransmitter, possibly dopamine, therefore acting similarly to dopamine reuptake inhibitor type antidepressants and stimulants.
"In populations where this parasite is very common, mass personality modification could result in cultural change. [Variations in the prevalence of Toxoplasma gondii] may explain a substantial proportion of human population differences we see in cultural aspects that relate to ego, money, material possessions, work and rules." — Kevin Lafferty
Correlations have been found between latent Toxoplasma infections and various characteristics:
  • Decreased novelty-seeking behaviour
  • Slower reactions
  • Lower rule-consciousness and jealousy (in men)
  • More warmth and conscientiousness (in women)
The evidence for behavioral effects on humans is relatively weak. There have been no randomized clinical trials studying the effects of toxoplasma on human behavior. Although some researchers have found potentially important associations with toxoplasma, it is possible that these associations merely reflect factors that predispose certain types of people to infection (e.g., people who exhibit risk-taking behaviors may be more likely to take the risk of eating undercooked meat).
Studies have found that toxoplasmosis is associated with an increased car accident rate, roughly doubling or tripling the chance of an accident relative to uninfected people. This may be due to the slowed reaction times that are associated with infection. The data shows that the risk decreases with time after infection, but is not due to age.However there is also evidence of a delayed effect which increases reaction times.
Other studies suggest that the parasite may influence personality. There are claims of toxoplasma causing antisocial attitudes in men and promiscuity (or even "signs of higher intelligence" ) in women, and greater susceptibility to schizophrenia and manic depression in all infected persons.
According to Sydney University of Technology infectious disease researcher Nicky Boulter in an article that appeared in the January/February 2007 edition of Australasian Science magazine, Toxoplasma infections lead to changes depending on the sex of the infected person.
The study suggests that male carriers have lower IQs, a tendency to achieve a lower level of education and have shorter attention spans, a greater likelihood of breaking rules and taking risks, and are more independent, anti-social, suspicious, jealous and morose. It also suggests that these men are deemed less attractive to women. Women carriers are suggested to be more outgoing, friendly, more promiscuous, and are considered more attractive to men compared with non-infected controls.

Toxoplasma's role in schizophrenia

The possibility that toxoplasmosis is one cause of schizophrenia has been studied by scientists since at least 1953.
These studies had attracted little attention from U.S. researchers until they were publicized through the work of prominent psychiatrist and advocate E. Fuller Torrey. In 2003, Torrey published a review of this literature, reporting that almost all the studies had found that schizophrenics have elevated rates of toxoplasma infection. These types of studies are suggestive but cannot confirm a causal relationship (because of the possibility, for example, that schizophrenia increases the likelihood of toxoplasma infection rather than the other way around).
  • Toxoplasma infection causes damage to astrocytes in the brain, and such damage is also seen in schizophrenia .

Human prevalence

The U.S. NHANES (1999-2004) national probability sample found that 10.8% of U.S. persons 6-49 years of age, and 11.0% of women 15-44 years of age, had Toxoplasma-specific IgG antibodies, indicating that they had been infected with the organism. This prevalence has significantly decreased from the NHANES III (1988-1994).
It is estimated that between 30% and 65% of all people worldwide are infected with Toxoplasmosis. However, there is large variation countries: in France, for example, around 88% of the population are carriers, probably due to a high consumption of raw and lightly cooked meat.
Germany, the Netherlands and Brazil also have high prevalences of around 80%, over 80% and 67% respectively. In Britain, about 22% are carriers, and South Korea's rate is only 4.3%. Proximity to freshwater outflows into the ocean were a major risk factor. Ingestion of oocysts from cat faeces is considered to be the most likely ultimate source. According to an article in the New Scientist, the parasites have also been found in dolphins and whales. Researchers Black and Massie believe that anchovies, which travel from estuaries into the open ocean, may be helping to spread the disease. Michael Grigg of the US National Institute of Health mentioned that a new type of T. gondii, type X, has been found which is responsible for the large deaths of sea otters, and may be "poised to sweep the world".

Notable people with toxoplasmosis

  • Martina Navrátilová (tennis player) retired from a competition in 1982 with symptoms of a mystery 'virus' that were later found to be due to toxoplasmosis
  • Arthur Ashe developed neurological problems from toxoplasmosis (and was later found to be HIV-positive)
  • Leslie Ash contracted toxoplasmosis in the second month of pregnancy
  • François, comte de Clermont, Dauphin of France and Orléans pretender to the French throne. Both he and his younger sister, Princess Blanche, are mentally disabled due to congenital toxoplasmosis.
  • Louis Wain was a prominent cat artist who later developed schizophrenia, which some believe was due to toxoplasmosis resulting from his prolonged exposure to cats.

References

External links

toxoplasmosis in Arabic: مقوسات
toxoplasmosis in Czech: Toxoplazmóza
toxoplasmosis in German: Toxoplasmose
toxoplasmosis in Modern Greek (1453-): Τοξοπλάσμωση
toxoplasmosis in Spanish: Toxoplasmosis
toxoplasmosis in French: Toxoplasmose
toxoplasmosis in Croatian: Toksoplazmoza
toxoplasmosis in Indonesian: Toksoplasmosis
toxoplasmosis in Italian: Toxoplasmosi
toxoplasmosis in Hebrew: טוקסופלזמוזיס
toxoplasmosis in Hungarian: Toxoplazmózis
toxoplasmosis in Malay (macrolanguage): Toxoplasmosis
toxoplasmosis in Dutch: Toxoplasmose
toxoplasmosis in Japanese: トキソプラズマ症
toxoplasmosis in Norwegian: Toksoplasmose
toxoplasmosis in Polish: Toksoplazmoza
toxoplasmosis in Portuguese: Toxoplasmose
toxoplasmosis in Russian: Токсоплазмоз
toxoplasmosis in Slovak: Toxoplazmóza
toxoplasmosis in Finnish: Toksoplasmoosi
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